Abstract b-AP15 and its derivatives block proteasome deubiquitinase (DUB) activity and have been developed and tested in the clinic as potential cancer therapeutic agents.b-AP15 induces apoptosis in cancer cells, but the underlying mechanisms are largely undefined.The current study focuses on studying the modulatory effects of b-AP15 on death recep
In vivo gluten challenge has been used since the early 1950s to study the role of cereal fractions in celiac disease.While early studies relied on crude indicators of celiac toxicity, the advent of jejunal biopsy and sophisticated immunohistochemical techniques has allowed accurate studies to be performed.Studies to determine the nature of the cere
Automated Vehicles aim to increase road safety as automated driving systems (ADS) take over the human driving task in the operational design domain (ODD), introducing severe challenges for safety validation.Pure driving over many kilometers to gather enough Events evidence for a safety argument is not feasible.Scenario-based testing is an approach
Despite the large amounts of resources destined to developing filtering algorithms of LiDAR point clouds in order to obtain a Digital Terrain Model (DTM), the task remains a challenge.As a society advancing towards the democratization of information and collaborative processes, the researchers should not only focus on improving the efficacy of filt
In this study, samples of Al-Mg-Sc alloy were investigated after friction stir processing with the addition of Mo powder.Holes were drilled into 5 mm-thick aluminum alloy sheets into which Mo powder was added at percentages of 5, 10, and 15 wt%.The workpieces with different powder contents were then subjected to four passes of friction stir process